This new research looks at the effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder.

The study found that six-week intensive treatments with either psilocybin or escitalopram (with psychological support) for MDD were associated with long-term improvements in depressive symptom severity. The greater degree of improvement in the PT arm at follow-up on psychosocial functioning, meaning in life, and psychological connectedness suggests warrant future research.